Synthesis and Biological Response of Size-Specific, Monodisperse Drug–Silica Nanoconjugates
نویسندگان
چکیده
منابع مشابه
Synthesis and biological response of size-specific, monodisperse drug-silica nanoconjugates.
Drug-containing nanoparticles (NPs) with monodisperse, controlled particle sizes are highly desirable for drug delivery. Accumulating evidence suggests that NPs with sizes less than 50 nm demonstrate superior performance in vitro and in vivo. However, it is difficult to fabricate monodisperse, drug-containing NPs with discrete sizes required for studying and characterizing existing relationship...
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The size of a nanomedicine strongly correlates with its biodistribution, tissue penetration, and cell uptake. However, there is limited understanding how the size of nanomedicine impacts the overall antitumor efficacy. We designed and synthesized camptothecin-silica nanoconjugates (Cpt-NCs) with monodisperse particle sizes of 50 and 200 nm, two representative sizes commonly used in drug deliver...
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ژورنال
عنوان ژورنال: ACS Nano
سال: 2012
ISSN: 1936-0851,1936-086X
DOI: 10.1021/nn300149c